PDPK1 activates PRKCZ

Stable Identifier
R-HSA-437195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

3-phosphoinositide dependent protein kinase-1 (Pdpk1, also known as Pdk1 and PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of protein kinase C zeta type (Prkcz, also known as PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that Pdpk1 might activate other PKCs.

Literature References
PubMed ID Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

Chou, MM, Hou, W, Johnson, J, Graham, LK, Lee, MH, Chen, CS, Newton, AC, Schaffhausen, BS, Toker, A

Curr Biol 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-phosphoinositide-dependent protein kinase activity of PDPK1:PIP3:PRKCZ [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created