PDK1 activates PKC zeta

Stable Identifier
R-HSA-437195
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

3-phosphoinositide dependent protein kinase-1 (PDK1, also known as PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of Protein kinase C zeta type (PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that PDK1 might activate other PKCs.

Literature References
PubMed ID Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 Curr Biol 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-phosphoinositide-dependent protein kinase activity of PIP3:PDK1:AKT:PKC zeta [plasma membrane]
Physical Entity
Activity
Inferred From