Reactome: A Curated Pathway Database

PDK1 activates PKC zeta (R-HSA-437195)

Species Homo sapiens


3-phosphoinositide dependent protein kinase-1 (PDK1, also known as PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of Protein kinase C zeta type (PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that PDK1 might activate other PKCs.

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Additional Information
Compartment cytosol , plasma membrane
Literature References
pubMedId Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1 Curr Biol 1998
Inferred Entries
Inferred From