Reactome: A Curated Pathway Database

Zinc influx into cells by the SLC39 gene family (R-HSA-442380) [Homo sapiens]


The SLC39 gene family encode zinc transporters belonging to the ZIP (Zrt-, Irt-like proteins) family of metal ion transporters. All ZIPs transport metal ions into the cytoplasm of cells, be it across cellular membranes or from intracellular compartments. To date, there are 14 human SLC39 genes that encode the zinc transporters hZIP1-14. There are 9 members which belong to a subfamily of the ZIPs called the LZTs (LIV-1 subfamily of ZIP zinc transporters) (Taylor KM and Nicholson RI, 2003). Of these 14 proteins, four (hZIP9, 11, 12 and 13) have no function determined yet (Eide DJ, 2004).

Literature References
pubMedId Title Journal Year
12748861 The SLC39 family of metal ion transporters Pflugers Arch 2004
12659941 The LZT proteins; the LIV-1 subfamily of zinc transporters Biochim Biophys Acta 2003