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CREB phosphorylation through the activation of CaMKK

Stable Identifier
R-HSA-442717
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Transient increase in intracellular Ca2+ concentration after NMDA receptor activation leads to the activation of the CaMKIV via the activation of CaM-kinase kinase. CaM-kinase kinase and CaMKIV are both activated upon binding Ca2+/Calmodulin after Ca2+ influx through activated NMDA receptor.

Literature References
PubMed ID Title Journal Year
18817731 Calmodulin-kinases: modulators of neuronal development and plasticity Neuron 2008
Participants
Participant Of