Reactome: A Curated Pathway Database

CREB phosphorylation through the activation of CaMKK (R-HSA-442717)

Species Homo sapiens


Transient increase in intracellular Ca2+ concentration after NMDA receptor activation leads to the activation of the CaMKIV via the activation of CaM-kinase kinase. CaM-kinase kinase and CaMKIV are both activated upon binding Ca2+/Calmodulin after Ca2+ influx through activated NMDA receptor.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000088, BIOMD0000000467
Literature References
pubMedId Title Journal Year
18817731 Calmodulin-kinases: modulators of neuronal development and plasticity Neuron 2008