Reactome: A Curated Pathway Database

CREB phosphorylation through the activation of CaMKII (R-HSA-442729) [Homo sapiens]


Ca2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-induced transcription. The isoforms of adenylate cyclase that are activated by Ca2+ in the brain are I, III and IX.

Additional Information
Compartment plasma membrane , cytosol , nucleoplasm
Literature References
pubMedId Title Journal Year
16799259 Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus J Pharmacol Sci 2006