Reactome: A Curated Pathway Database

CREB phosphorylation through the activation of CaMKII

Stable Identifier
R-HSA-442729
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Ca2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-induced transcription. The isoforms of adenylate cyclase that are activated by Ca2+ in the brain are I, III and IX.

Literature References
Participants
Participant Of
Orthologous Events