Reactome: A Curated Pathway Database

Ras activation

Stable Identifier
R-HSA-442732
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of RasGRF to Ca2+/Calmodulin in the presence of high Ca2+ leads to the activation of Ras. Activation of Ras involves the exchange of GDP for GTP.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Ras guanyl-nucleotide exchange factor activity of RasGRF:Ca/calmodulin [plasma membrane] RasGRF:Ca/calmodulin [plasma membrane] Ras guanyl-nucleotide exchange factor activity (0005088)
Orthologous Events