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Ras activation (R-HSA-442732) [Homo sapiens]

Reaction
Summation

Binding of RasGRF to Ca2+/Calmodulin in the presence of high Ca2+ leads to the activation of Ras. Activation of Ras involves the exchange of GDP for GTP.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane , extracellular region
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
RasGRF:Ca/calmodulin Ras guanyl-nucleotide exchange factor activity (0005088)  
Literature References
pubMedId Title Journal Year
14622581 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1 Neuron 2003
Inferred Entries
Orthologous events
 
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