Reactome: A Curated Pathway Database

Phosphorylation by PDK1

Stable Identifier
R-HSA-442739
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PDK1 activates ribosomal S6 kinase (RSK) by phosphorylating S221. The binding site for PDK1 on RSK is available after RSK phosphorylation by MAPK/ERK. PDK1 is present in the activated form at the plasma membrane where the phosphorylation occurs. The activation of RSK occurs in the cytoplasm, plasma membrane and in the nucleus where it finally activates CREB by phosphorylation.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
kinase activity of PDPK1 [nucleoplasm] PDPK1 [nucleoplasm] kinase activity (0016301)
Orthologous Events