Reactome: A Curated Pathway Database

CREB phosphorylation through the activation of Ras

Stable Identifier
R-HSA-442742
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB) at serine 133 which is involved in the transcription of genes that results in long lasting changes in the synapse. The phosphorylation of CREB by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase, activation of CaMKII and/or the activation of CaMKIV.

Literature References
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Orthologous Events