Reactome: A Curated Pathway Database

CREB phosphorylation through the activation of Ras (R-HSA-442742)

Species Homo sapiens


Ca2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca2+ within the spine leads to phosphorylation of Cyclic AMP Response Element binding protein (CREB) at serine 133 which is involved in the transcription of genes that results in long lasting changes in the synapse. The phosphorylation of CREB by increased Ca2+ can be brought about by distinct molecular pathways that may involve MAP kinase, activation of adenylate cyclase, activation of CaMKII and/or the activation of CaMKIV.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol , nucleoplasm
Literature References
pubMedId Title Journal Year
12819448 Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway J Am Acad Child Adolesc Psychiatry 2003