Reactome: A Curated Pathway Database

Activation of CaMKK (R-HSA-442749)

Species Homo sapiens


CaMKK is fully activated upon binding Ca2+/Calmodulin after intracellular Ca2+ levels increase. Once CaMKK binds Ca2+/Calmodulin it autophosphorylates, resulting in activation. CaMKK is negatively regulated by phosphorylation of S74 and T108 by PKA. Once activated CaMKK phosphorylates CaMKIV in a Ca2+/Calmodulin dependent manner.

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Additional Information
Compartment cytosol
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Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
CAMKK1 calmodulin-dependent protein kinase activity (0004683)