Reactome: A Curated Pathway Database

Activation of CaMKK

Stable Identifier
R-HSA-442749
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CaMKK is fully activated upon binding Ca2+/Calmodulin after intracellular Ca2+ levels increase. Once CaMKK binds Ca2+/Calmodulin it autophosphorylates, resulting in activation. CaMKK is negatively regulated by phosphorylation of S74 and T108 by PKA. Once activated CaMKK phosphorylates CaMKIV in a Ca2+/Calmodulin dependent manner.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
calmodulin-dependent protein kinase activity of CAMKK1 [cytosol] CAMKK1 [cytosol] calmodulin-dependent protein kinase activity (0004683)
Orthologous Events