Reactome: A Curated Pathway Database
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Cis-heterodimerization of NgCAM and DM-GRASP/ALCAM

Stable Identifier
R-GGA-443781
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

DM GRASP/ALCAM/BEN is one of the heterodimerizing partners for L1/NgCAM. Interation between L1/NgCAM and DM GRASP in the growth cone membrane is involved in L1 stimulated neurite outgrowth. Trans binding of L1 on retinal growth cones to ALCAM on the superior colliculus potentiates adhesion, leading to correct synaptic targeting.

Literature References
Participants
Participant Of
Orthologous Events