Reactome: A Curated Pathway Database

RSK activation (R-HSA-444257)

Species Homo sapiens


Ribosomal S6 kinase has four isoforms in humans and each of the isoforms have sic conserved phosphorylation sites (S221, S363, S380,S749, T359,T573) out of which four are important for its activity (S221, S363, 380,T573).
Phosphorylation and activation of ribosomal S6 Kinase (RSK) occurs at the plasma membrane, cytoplasm and in the nucleus. Phosphorylation of RSK first occurs at residue T573 followed by S363 an S380 by activated MAPK/ERK . This form is then phosphorylated by PDK1, which is active in the plasm membrane by an autophosphorylation event.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000255
Literature References
pubMedId Title Journal Year
18813292 The RSK family of kinases: emerging roles in cellular signalling Nat Rev Mol Cell Biol 2008