Reactome: A Curated Pathway Database

Formyl peptide receptors bind formyl peptides and many other ligands

Stable Identifier
R-HSA-444473
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF). FPR was cloned in 1990 and the cDNA used as a probe to identify two additional genes, FPRL1 and FPRL2. The three genes for a cluster on 19q13.3. All are coupled to the Gi family of G proteins.
All 3 receptors can be activated by formyl peptides but also display affinities for a range of structurally diverse ligands.

Literature References
Participants
Participant Of
Orthologous Events