Reactome: A Curated Pathway Database

CaMKII enters cytoplasm

Stable Identifier
R-HSA-445367
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CaMKII gets activated upon Ca2+ influx through the NMDA receptor and moves from plasma membrane to cytoplasm and then nucleus where it phosphorylates CREB at serine 133.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
excitatory extracellular ligand-gated ion channel activity of NMDA receptor ligand complex [plasma membrane] NMDA receptor ligand complex [plasma membrane] excitatory extracellular ligand-gated ion channel activity (0005231)
Orthologous Events