Reactome: A Curated Pathway Database
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ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-445699
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once ATP is bound, myosin, which is an ATPase, uses the energy from the cleavage of the terminal phosphate to pivot the myosin head back, away from the actin filamentous chain. This change in conformation "resets" the myosin molecule, leaving it ready to bind the actin filament once more and slide the myosin filament along the actin filament, continuing the contractile cycle.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
myosin phosphatase activity of ATP Bound Smooth Muscle Myosin Complex [cytosol] ATP Bound Smooth Muscle Myosin Complex [cytosol] myosin phosphatase activity (0017018)
Orthologous Events