Reactome: A Curated Pathway Database

ATP Hydrolysis By Myosin (R-HSA-445699) [Homo sapiens]


Once ATP is bound, myosin, which is an ATPase, uses the energy from the cleavage of the terminal phosphate to pivot the myosin head back, away from the actin filamentous chain. This change in conformation "resets" the myosin molecule, leaving it ready to bind the actin filament once more and slide the myosin filament along the actin filament, continuing the contractile cycle.

Additional Information
Compartment cytosol
Catalyst Activity
PhysicalEntity Activity Active Units
ATP Bound Smooth Muscle Myosin Complex myosin phosphatase activity (0017018)