Reactome: A Curated Pathway Database

Calcium Binds Caldesmon (R-HSA-445704)

Species Homo sapiens

Summation

Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
11457814 Invited review: cross-bridge regulation by thin filament-associated proteins J Appl Physiol 2001
1930128 The molecular anatomy of caldesmon Biochem J 1991