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Calcium Binds Caldesmon
Stable Identifier
R-HSA-445704
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding.
Literature References
PubMed ID
Title
Journal
Year
11457814
Invited review: cross-bridge regulation by thin filament-associated proteins
Gangopadhyay, SS
,
Morgan, KG
J Appl Physiol
2001
1930128
The molecular anatomy of caldesmon
Marston, SB
,
Redwood, CS
Biochem J
1991
Participants
Input
Ca2+ [cytosol]
Inactive Myosin Actin Contractile Complex [plasma membrane]
(Homo sapiens)
Output
Calcium Bound Myosin Actin Complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Smooth Muscle Contraction (Homo sapiens)
Orthologous Events
Calcium Binds Caldesmon (Bos taurus)
Calcium Binds Caldesmon (Caenorhabditis elegans)
Calcium Binds Caldesmon (Canis familiaris)
Calcium Binds Caldesmon (Drosophila melanogaster)
Calcium Binds Caldesmon (Gallus gallus)
Calcium Binds Caldesmon (Mus musculus)
Calcium Binds Caldesmon (Rattus norvegicus)
Calcium Binds Caldesmon (Sus scrofa)
Authored
Gillespie, ME (2003-07-01)
Reviewed
Rush, MG (2008-01-11)
Created
Gillespie, ME (2009-11-05)
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