Reactome | IL1RAP-1 [plasma membrane]

IL1RAP-1 [plasma membrane]

Stable Identifier

R-HSA-445745

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

mIL1RAP, Interleukin-1 receptor accessory protein, membrane associated isoform, mIL-1RAcP, IL-1RAcP, IL1AP_HUMAN, Membrane-bound IL-1RAcP, IL1RAP isoform 1, IL-1R3

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RAP-1 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Homo sapiens)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Homo sapiens)
        
        IL1RAP-1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPH3-1 IL1RAP

Gene Names

IL1RAP, C3orf13, IL1R3

Other Identifiers

11729098_a_at

11729099_a_at

11732585_a_at

11761995_a_at

16949584

205227_PM_at

205227_at

210233_PM_at

210233_at

2657835

2657836

2657845

2657848

2657857

2657858

2657860

2657865

2657866

2657867

2657872

2657873

2657874

2657875

2657876

2657881

2657882

2657883

2657884

2657885

2657886

2657887

2657888

2657889

2657890

2657891

2657892

2657893

3556

38546_at

51136_at

8084794

A_14_P111968

A_21_P0000070

A_23_P170857

A_23_P336554

A_24_P148762

A_24_P180165

GE53127

GE900526

GE903664

GO:0002114

GO:0002376

GO:0003824

GO:0003953

GO:0004908

GO:0005149

GO:0005576

GO:0005886

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0015026

GO:0016020

GO:0016787

GO:0019221

GO:0023052

GO:0032736

GO:0032753

GO:0032754

GO:0032755

GO:0034330

GO:0038172

GO:0045087

GO:0045202

GO:0048856

GO:0050135

GO:0051965

GO:0060089

GO:0061809

GO:0065003

GO:0070498

GO:0098542

GO:0098978

GO:0099151

GO:0099545

GO:0099560

GO:1905606

HMNXSV003033302

HMNXSV003037537

HMNXSV003050674

ILMN_1686884

ILMN_1793870

ILMN_2357062

PH_hs_0022571

g4504660_3p_x_at

g8050486_3p_at

Participates

as a component of

as an input of

Inferred To

IL1RAP-1 [plasma membrane] (Gallus gallus)

Ghost homologue of IL1RAP-1 [plasma membrane] (Sus scrofa)

il1rap [plasma membrane] (Xenopus tropicalis)

Il1rap [plasma membrane] (Mus musculus)

Il1rap [plasma membrane] (Rattus norvegicus)

IL1RAP [plasma membrane] (Bos taurus)

IL1RAP [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001161402.1, NP_001161401.1, NP_608273.1, NP_001161403.1, NP_001161400.1, NP_002173.1

OpenTargets

ENSG00000196083

IntEnz

3.2.2.6

GeneCards

Q9NPH3

HPA

ENSG00000196083-IL1RAP

Ensembl

ENSP00000345829, ENST00000439062, ENST00000072516, ENSG00000196083, ENSP00000314807, ENST00000342550, ENSP00000390541, ENSP00000416296, ENSP00000409352, ENST00000447382, ENST00000413869, ENST00000422940, ENST00000317757, ENSP00000072516, ENSP00000401132, ENST00000422485, ENSP00000387371

PRO

Q9NPH3

Pharos - Targets

Q9NPH3

HMDB Protein

HMDBP12401

PDB

7FCC, 4DEP, 3O4O

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01584 IL1B	4	IL1B [extracellular region] (R-HSA-445748) IL1B(1-116) [cytosol] (R-HSA-449030) IL1B(117-269) [cytosol] (R-HSA-449046) IL1B(1-269) [cytosol] (R-HSA-448689)	0.77	7
UniProt:P14778 IL1R1	1	IL1R1 [plasma membrane] (R-HSA-197595)	0.667	3
UniProt:P27930 IL1R2	1	IL1R2 [plasma membrane] (R-HSA-197598)	0.524	2

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