Reactome: A Curated Pathway Database

TAK1 activates NFkB by phosphorylation and activation of IKKs complex (R-HSA-445989)

Species Homo sapiens


NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression.

Locations in the PathwayBrowser
Immune System(Homo sapiens)

TRAF6 Mediated Induction of proinflammatory cytokines(Homo sapiens)
Additional Information
Compartment cytosol , nucleoplasm
GO Biological Process positive regulation of NF-kappaB transcription factor activity (0051092)
Cross References
Database Identifier
BioModels Database BIOMD0000000243, BIOMD0000000477, BIOMD0000000407