Reactome: A Curated Pathway Database

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Stable Identifier
R-HSA-445989
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression.

Literature References
Participants
Participant Of
Orthologous Events
Cross References