Reactome: A Curated Pathway Database

Formation of the BRCA1-PALB2-BRCA2 complex (R-HSA-446345)

Species Homo sapiens


BRCA2 plays a critical role in the initiation of DNA repair by loading the repair protein RAD51 onto single-stranded DNA for homologous recombination (HR) (Reviewed in Lord and Ashworth, 2007). PALB2 associates with BRCA2 and also functions in the loading of the the BRCA2-RAD51 repair complex onto DNA (Xia et al., 2006 ). BRCA1, through its direct interaction with PALB2, may regulate recombinational repair partly by modulating the PALB2- dependent loading of the BRCA2-RAD51 repair machinery at the sites of DNA breaks (Sy et al., 2009).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
19369211 PALB2 is an integral component of the BRCA complex required for homologous recombination repair Proc Natl Acad Sci U S A 2009