Interaction of Bnip-2 with Cdc42

Stable Identifier
R-MMU-448947
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of Bnip-2 with Cdc42
Bnip-2 interacts with Cdc42 through its Bnip-2 and Cdc42GAP homology (BCH) domain and thus it acts as a linkage between the CDO receptor and the Cdc42 activity. Formation of a CDO-Bnip-2-Cdc42 complex stimulates Cdc42 activation which in turn promotes p38 alpha/beta activity and cell differentiation.
Literature References
PubMed ID Title Journal Year
19244314 Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway

Kang, JS, Bae, GU, Lee, HJ, Kim, BG, Yi, MJ, Oh, JE, Yang, YJ, Krauss, RS

FASEB J 2009
15652341 BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain

Low, BC, Zhou, YT, Guy, GR

Exp Cell Res 2005
18678706 A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation

Kang, JS, Takaesu, G, Bae, GU, Low, BC, Yi, MJ, Oh, JE, Zhou, YT, Yang, YJ, Krauss, RS

J Cell Biol 2008
Participants
Input
Output
Orthologous Events
Interaction of Bnip-2 with Cdc42 (Homo sapiens)
Authored
Garapati, P V  (2008-08-11)
Reviewed
Krauss, RS  (2010-02-09)
Created
Garapati, P V  (2009-11-26)
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