Reactome: A Curated Pathway Database

Activation of p38 alpha/beta MAPK

Stable Identifier
R-HSA-448951
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

p38 alpha/beta MAPK is well established as a promyogenic kinase, but the mechanism by which it is activated during differentiation is not well understood. CDO, JLP and p38 form a ternary complex and it is anticipated that in its role as a scaffold, JLP brings additional components of the pathway, such as MKKs, to these complexes and cooperate to activate p38 alpha/beta MAPK pathway. p38 is activated by phosphorylation on a canonical TxY motif by dual specificity kinases MKK6 and MKK3. MKK6 is the most abundant in skeletal muscles and displays minimal substrate selectivity among all p38 isoforms.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
MAP kinase kinase activity of p-S207,T211-MAP2K6 [cytosol] p-S207,T211-MAP2K6 [cytosol] MAP kinase kinase activity (0004708)
Inferred From