Reactome: A Curated Pathway Database

Activation of p38 alpha/beta MAPK (R-HSA-448951)

Species Homo sapiens


p38 alpha/beta MAPK is well established as a promyogenic kinase, but the mechanism by which it is activated during differentiation is not well understood. CDO, JLP and p38 form a ternary complex and it is anticipated that in its role as a scaffold, JLP brings additional components of the pathway, such as MKKs, to these complexes and cooperate to activate p38 alpha/beta MAPK pathway. p38 is activated by phosphorylation on a canonical TxY motif by dual specificity kinases MKK6 and MKK3. MKK6 is the most abundant in skeletal muscles and displays minimal substrate selectivity among all p38 isoforms.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
p-S207,T211-MAP2K6 MAP kinase kinase activity (0004708)
Inferred Entries
Inferred From