Reactome: A Curated Pathway Database
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Signaling by Interleukins

Stable Identifier
R-HSA-449147
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Signaling by Interleukins and related cytokines
Locations in the PathwayBrowser
Summation

Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

Literature References
PubMed ID Title Journal Year
Participants
events
Participant Of
Orthologous Events