Reactome: A Curated Pathway Database

Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

Stable Identifier
R-HSA-450027
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The crystal structure of the assembled IL2:IL2 receptor complex and experiments using isothermal titration calorimetry suggest that the complex of IL2 with IL2R alpha is likely to preferentially associate with IL2R bet (Rickert et al. 2004, Stauber et al. 2006). Binding of IL-2/IL-2R alpha to IL-2R beta significantly slows the dissociation of IL-2. However, the trimeric complex of IL-2:IL-2R alpha:IL-2R beta is incapable of signaling without participation of the gamma chain.

Literature References
Participants
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Orthologous Events