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About
What is Reactome ?
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Icon Info
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Computational inferred events
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IL2RA
Stable Identifier
R-HSA-450046
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-2 receptor alpha chain, IL2RA_HUMAN, CD25
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated STAT5 is released (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Recruited STAT5 is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
SYK is a substrate for JAK1 (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin-3, 5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PI3Kgamma (Homo sapiens)
PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01589 IL2RA
Gene Names
IL2RA
Chain
signal peptide:1-21, chain:22-272
Reference Genes
BioGPS Gene:3559 IL2RA
COSMIC (genes):IL2RA IL2RA
CTD Gene:3559 IL2RA
dbSNP Gene:3559 IL2RA
ENSEMBL:ENSG00000134460 IL2RA
HGNC:6008 IL2RA
KEGG Gene (Homo sapiens):hsa:3559 IL2RA
Monarch:3559 IL2RA
NCBI Gene:3559 IL2RA
OMIM:147730 IL2RA
UCSC:P01589 IL2RA
Reference Transcript
RefSeq:NM_001308242.1 IL2RA
RefSeq:NM_001308243.1 IL2RA
RefSeq:NM_000417.2 IL2RA
Other Identifiers
0006900014
11739954_at
11739955_a_at
11752775_a_at
16711501
1702_at
1ILM
1ILN
1Z92
206341_at
211269_s_at
2419
2B5I
2ERJ
3275730
3275731
3275732
3275733
3275734
3275743
3275746
3275747
3275748
3275751
3275752
3275758
3275759
3275760
3275769
3275770
3275771
3559
3IU3
3NFP
54622
77706_at
7931914
A_23_P127288
A_24_P230563
CAB002419
CCDS7076
ENSG00000134460
ENSP00000369287
ENSP00000369293
ENST00000379954
ENST00000379959
EntrezGene:3559
g186319_3p_a_at
GE59635
GO:0000165
GO:0002376
GO:0002437
GO:0002664
GO:0004911
GO:0005088
GO:0005515
GO:0005622
GO:0005886
GO:0006915
GO:0006924
GO:0006954
GO:0006955
GO:0007166
GO:0007219
GO:0008144
GO:0008283
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0019976
GO:0038110
GO:0042102
GO:0042104
GO:0042130
GO:0043029
GO:0043547
GO:0045582
GO:0045589
GO:0046013
GO:0050672
GO:0050687
GO:0050728
GO:0050777
GO:0065009
HGNC:6008
HPA054622
Hs.231367
IL2RA
IL2RA-203
ILMN_1683774
ILMN_2108699
LRG_73
LRG_73t1
MIM:147730
MIM:601942
MIM:606367
NM_000417
NP_000408
PF00084
PH_hs_0022432
Q5W005
SM00032
TC10001007.hg
uc001iiz.3
UPI000012D4A3
X01057_at
Participant Of
input
Interleukin-2 receptor alpha binds interleukin-2
hasComponent
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]
IL2:IL2RA [plasma membrane]
IL2RA:IL2RB:p-JAK1 [plasma membrane]
output
IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1
Inferred To
IL2RA [plasma membrane] (Bos taurus)
IL2RA [plasma membrane] (Canis familiaris)
IL2RA [plasma membrane] (Mus musculus)
IL2RA [plasma membrane] (Rattus norvegicus)
IL2RA [plasma membrane] (Sus scrofa)
Ghost homologue of IL2RA [plasma membrane] (Danio rerio)
Ghost homologue of IL2RA [plasma membrane] (Taeniopygia guttata)
Homologues of IL2RA [plasma membrane] (Canis familiaris)
Cross References
RefSeq
NP_001295172.1
,
NP_001295171.1
,
NP_000408.1
ZINC - Substances
IL2RA_HUMAN
GeneCards
P01589
DOCK Blaster
2ERJ
,
3IU3
,
2B5I
,
1Z92
,
3NFP
ZINC target
P01589
PRO
P01589
Orphanet
17467
ZINC - Predictions - Purchasable
IL2RA_HUMAN
PDB
1ILM
,
2ERJ
,
3IU3
,
1ILN
,
3NFP
,
1Z92
,
2B5I
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60568 IL2
1
IL2 [extracellular region]
(R-HSA-447099)
0.667
3
UniProt:O75360 PROP1
0.488
2
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