Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.
|16477002||Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor||Proc Natl Acad Sci U S A||2006|
|15178252||Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors||J Mol Biol||2004|