Reactome: A Curated Pathway Database
THIS SITE IS USED FOR RELEASE TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (R-HSA-450063) [Homo sapiens]

Reaction
Summation

Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.

Additional Information
Compartment plasma membrane