Reactome: A Curated Pathway Database

Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (R-HSA-450063) [Homo sapiens]


Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.

Additional Information
Compartment plasma membrane