RNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-element binding proteins is regulated, usually by phosphorylation but also by subcellular localization.
|Compartment||cytosol , nucleoplasm|
|GO Biological Process||regulation of mRNA stability (0043488)|
|16391004||AU-rich elements and associated factors: are there unifying principles?||Nucleic Acids Res||2005|
|12704645||Post-transcriptional regulation of gene expression by degradation of messenger RNAs||J Cell Physiol||2003|
|12440953||AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors||Biochem Soc Trans||2002|
|15460540||AU-rich elements and the control of gene expression through regulated mRNA stability||Anim Health Res Rev||2004|