Although functional assays showed that chicken cells respond to known mammalian TLR7 and TLR9 ligands in vitro and in ovo [Philbin et al 2005, Jenkins KA et al 2009], bioinformatics analysis of the chicken genome have identified a disrupted ortholog of TLR8 and no direct ortholog of TLR9. Only TLR7 gene was found intact[Philbin et al 2005, Temperley ND et al 2008].The chicken TLR7 (chTLR7) amino acid sequence shows 62% identity to its human counterpart. chTLR7 mRNA was detected in immune-related tissues - spleen, caecal tonsil [Iqbal et al 2005, Phiblin et al 2005]. Chicken leukocytes, heterophils, monocytes and the chicken macrophage cell line HD11 have been also shown to express chTLR7 [Philbin et al 2005].
Burt, DW, Berlin, S, Temperley, ND, Griffin, DK, Paton, IR
Smith, AL, Boyd, Y, Bumstead, N, Beal, RK, Goodchild, MJ, Young, J, Iqbal, M, Philbin, VJ
Smith, A, Philbin, V, Kogut, MH, Kaiser, P, He, H, Iqbal, M
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