Interleukin-2 family signaling

Stable Identifier
R-HSA-451927
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The interleukin-2 family (also called the common gamma chain cytokine family) consists of interleukin (IL)2, IL9, IL15 and IL21. Although sometimes considered to be within this family, the IL4 and IL7 receptors can form complexes with other receptor chains and are represented separately in Reactome. Receptors of this family associate with JAK1 and JAK3, primarily activating STAT5, although certain family members can also activate STAT1, STAT3 or STAT6.

Literature References
PubMed ID Title Journal Year
18817510 Structural biology of shared cytokine receptors Annu Rev Immunol 2009
25200249 The IL-2 cytokine family in cancer immunotherapy Cytokine Growth Factor Rev. 2014
19543225 New insights into the regulation of T cells by gamma(c) family cytokines Nat Rev Immunol 2009
Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database