Reactome: A Curated Pathway Database

Phosphorylation of IL2RB Y338 enables SHC recruitment (R-HSA-452091)

Species Homo sapiens

Summation

Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane