Reactome | Phosphorylation of IL2RB Y338 enables SHC recruitment

Phosphorylation of IL2RB Y338 enables SHC recruitment

Stable Identifier

R-HSA-452091

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylation of IL2RB Y338 enables SHC recruitment

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Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes.

Literature References

PubMed ID	Title	Journal	Year
8643566	Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling Igras, V, Fesik, SW, Shoelson, SE, Ravichandran, KS, Burakoff, SJ	Proc Natl Acad Sci U S A	1996
8700888	Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation Friedmann, MC, Russell, SM, Migone, TS, Leonard, WJ	Proc Natl Acad Sci U S A	1996
7499411	Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association Howard, OM, Erwin, R, Goldsmith, MA, Abraham, RT, Evans, GA, Greene, WC, Johnston, JA, Xu, W, O'Shea, JJ, Weiler, SR	J Biol Chem	1995