Reactome: A Curated Pathway Database

Phosphorylation of IL2RB Y338 enables SHC recruitment

Stable Identifier
R-HSA-452091
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes.

Literature References
Participants
Participant Of
Orthologous Events