Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes.
|8700888||Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation||Proc Natl Acad Sci U S A||1996|
|8643566||Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling||Proc Natl Acad Sci U S A||1996|
|7499411||Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association||J Biol Chem||1995|