Reactome: A Curated Pathway Database

JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Following stimulation by IL2, the IL2R beta chain become phosphorylated on multiple tyrosine residues. These phosphotyrosine residues recruit position-specific signaling or adaptor proteins, leading to the activation of downstream signaling pathways. Although multiple kinases are involved in the phosphorylation of IL-2R beta, JAK1-dependent phosphorylation of tyrosines 338, 392 and 510 is known to be involved in STAT protein binding (Gaffen et al. 1996). Phospho-tyrosine 338 has also been shown to participate in recruitment and subsequent phosphorylation of the adaptor Shc (Friedmann et al. 1996). N.B. Numbering in the literature is based on the mature peptide, with the 26 residue signal peptide removed. Positions given in this reaction refer to the canonical Uniprot sequence, e.g. 338 is equivalent to 364 of the canonical sequence P14784.

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events