Reactome: A Curated Pathway Database

Syk autophosphorylates (R-HSA-453200)

Species Homo sapiens

Summation

Binding of Syk causes conformational changes that lead to Syk activation by autophosphorylation. Syk can be activated by a number of phosphorylation events, and it has been proposed that Syk may function as a switch whereby any of several possible stimuli trigger the acquisition of similar activated conformations. (Tsang et al. 2008). These phosphorylations both modulate Syk's catalytic activity (Keshvara et al. 1997) and generate docking sites for SH2 domain-containing proteins, such as c-Cbl, PLC, and Vav1. Syk tyrosine phosphorylation is reduced in the presence of the ITIM-containing immunoglobulin superfamily transmembrane protein G6B (Mori et al. 2008).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
This entry is regulated by
Regulation type Name
NegativeRegulation