Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

SYK autophosphorylates

Stable Identifier
R-HSA-453200
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding of Syk causes conformational changes that lead to Syk activation by autophosphorylation. Syk can be activated by a number of phosphorylation events, and it has been proposed that Syk may function as a switch whereby any of several possible stimuli trigger the acquisition of similar activated conformations. (Tsang et al. 2008). These phosphorylations both modulate Syk's catalytic activity (Keshvara et al. 1997) and generate docking sites for SH2 domain-containing proteins, such as c-Cbl, PLC, and Vav1. Syk tyrosine phosphorylation is reduced in the presence of the ITIM-containing immunoglobulin superfamily transmembrane protein G6B (Mori et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
non-membrane spanning protein tyrosine kinase activity of GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] non-membrane spanning protein tyrosine kinase activity (0004715)
Orthologous Events