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APP(18-770)

Stable Identifier
R-HSA-49335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
APP, Amyloid beta A4 protein precursor, ABPP, Alzheimer's disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, Soluble APP-alpha, S-APP- alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AID(59), Gamma-CTF(57), Gamma- secretase C-terminal fragment 57, Amyloid intracellular domain 57, AID(57), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AID(50), C31
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
APP, A4, AD1
Chain
signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
Other Identifiers
0001230601
11738008_s_at
11741216_x_at
11742210_a_at
11742211_x_at
11742215_s_at
11746866_a_at
11750384_a_at
11751350_a_at
11752199_a_at
11752200_x_at
11752481_a_at
11762804_x_at
1462
157
16924551
1AAP
1AMB
1AMC
1AML
1BA4
1BA6
1BJB
1BJC
1BRC
1CA0
1HZ3
1IYT
1MWP
1OWT
1QCM
1QWP
1QXC
1QYT
1TAW
1TKN
1UO7
1UO8
1UOA
1UOI
1X11
1Z0Q
1ZE7
1ZE9
1ZJD
200602_at
211277_3p_x_at
211277_x_at
214953_s_at
2BEG
2BOM
2BP4
2FJZ
2FK1
2FK2
2FK3
2FKL
2FMA
2G47
2IPU
2LFM
2LLM
2LMN
2LMO
2LMP
2LMQ
2LNQ
2LOH
2LP1
2LZ3
2LZ4
2M4J
2M9R
2M9S
2MGT
2MJ1
2MPZ
2MVX
2MXU
2NAO
2OTK
2R0W
2WK3
2Y29
2Y2A
2Y3J
2Y3K
2Y3L
351
3927227
3927228
3927229
3927230
3927233
3927234
3927237
3927241
3927242
3927262
3927264
3927271
3927272
3927273
3927274
3927281
3927282
3927289
3927298
3927300
3927301
3927306
3927307
3927320
3927335
3927336
3AYU
3BAE
3BKJ
3DXC
3DXD
3DXE
3GCI
3IFL
3IFN
3IFO
3IFP
3JQ5
3JQL
3JTI
3KTM
3L33
3L81
3MOQ
3MXC
3MXY
3NYJ
3NYL
3OVJ
3OW9
3SV1
3U0T
3UMH
3UMI
3UMK
41136_s_at
4HIX
4JFN
4M1C
4MDR
4MVI
4MVK
4MVL
4NGE
4OJF
4ONF
4ONG
4PQD
4PWQ
4XXD
5AEF
5AM8
5AMB
5BUO
5C67
5CSZ
5HOW
5HOX
5HOY
5KK3
5KNA
64309_f_at
8069644
A0A140VJC8
A_24_P314159
A_33_P3296479
A_33_P3508822
AAA35540
AAA51564
AAA51722
AAA51726
AAA51727
AAA51768
AAA58727
AAA60163
AAB23646
AAB26263
AAB26264
AAB26265
AAB59501
AAB59502
AAC13654
AAC60601
AAH04369
AAH65529
AAQ14327
AAW82435
AB066441
AEE60915
AF282245
AK295621
AK312326
AP001439
AP001440
AP001441
AP001442
AP001443
APP
APP-201
APP-202
APP-203
APP-204
APP-205
APP-209
AY919674
BAA22264
BAB71958
BAG35248
BAG58500
BC004369
BC065529
CAA30041
CAA30042
CAA30050
CAA31830
CAA68374
CAB000157
CCDS13576
CCDS13577
CCDS33523
CCDS46638
CCDS56212
CCDS56213
CH471079
D87675
EAX09958
EAX09959
EAX09960
EAX09961
EAX09963
EAX09965
ENSG00000142192
ENSP00000284981
ENSP00000345463
ENSP00000346129
ENSP00000350578
ENSP00000351796
ENSP00000387483
ENST00000346798
ENST00000348990
ENST00000354192
ENST00000357903
ENST00000358918
ENST00000440126
EntrezGene:351
g4502166_3p_at
GE57419
GO:0000003
GO:0000278
GO:0000902
GO:0001934
GO:0001967
GO:0002376
GO:0002576
GO:0003674
GO:0003677
GO:0004867
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005641
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005790
GO:0005791
GO:0005794
GO:0005796
GO:0005829
GO:0005856
GO:0005886
GO:0005887
GO:0005905
GO:0005911
GO:0005929
GO:0006378
GO:0006397
GO:0006412
GO:0006417
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0006878
GO:0006897
GO:0006915
GO:0006950
GO:0006979
GO:0007049
GO:0007155
GO:0007165
GO:0007176
GO:0007219
GO:0007267
GO:0007399
GO:0007409
GO:0007568
GO:0007611
GO:0007617
GO:0007626
GO:0008088
GO:0008150
GO:0008201
GO:0008203
GO:0008219
GO:0008344
GO:0008542
GO:0009058
GO:0009986
GO:0009987
GO:0010288
GO:0010466
GO:0010468
GO:0010951
GO:0010952
GO:0010971
GO:0016020
GO:0016021
GO:0016192
GO:0016199
GO:0016322
GO:0016358
GO:0016504
GO:0019899
GO:0021700
GO:0022607
GO:0030134
GO:0030154
GO:0030198
GO:0030234
GO:0030414
GO:0030424
GO:0030426
GO:0030705
GO:0030900
GO:0031093
GO:0031175
GO:0031410
GO:0031594
GO:0031904
GO:0032588
GO:0034641
GO:0035235
GO:0035253
GO:0040007
GO:0040011
GO:0040014
GO:0042592
GO:0042802
GO:0043005
GO:0043167
GO:0043195
GO:0043197
GO:0043198
GO:0043226
GO:0043235
GO:0043393
GO:0043687
GO:0044267
GO:0044281
GO:0044304
GO:0045087
GO:0045121
GO:0045177
GO:0045202
GO:0045665
GO:0045931
GO:0045944
GO:0046872
GO:0046914
GO:0048167
GO:0048471
GO:0048669
GO:0048856
GO:0050803
GO:0050808
GO:0050877
GO:0050885
GO:0051124
GO:0051233
GO:0051247
GO:0051402
GO:0051425
GO:0051563
GO:0055085
GO:0070062
GO:0070851
GO:0071320
GO:0071874
GO:0090647
GO:0097449
GO:1990000
GO:1990090
GO:1990761
GO:1990812
GO:2000310
HGNC:620
HM005315
HPA001462
Hs.177486.2.A1_3p_a_at
Hs.434980
ILMN_1653283
ILMN_1678152
ILMN_2404063
ILMN_2404065
IPR002223
IPR008154
IPR008155
IPR011178
IPR013803
IPR015849
IPR019543
IPR019744
IPR019745
IPR020901
IPR024329
IPR028866
M15532
M15533
M16765
M18734
M24546
M24547
M28373
M29269
M29270
M33112
M34862
M34863
M34864
M34865
M34866
M34867
M34868
M34869
M34870
M34871
M34872
M34873
M34874
M34875
M34876
M34877
M34878
M34879
M35675
M37895
M37896
MIM:104300
MIM:104760
MIM:605714
NM_000484
NM_001136016
NM_001136129
NM_001204301
NM_001204302
NM_001204303
NM_201413
NM_201414
NP_000475
NP_001129488
NP_001129601
NP_001191230
NP_001191231
NP_001191232
NP_958816
NP_958817
PF00014
PF02177
PF03494
PF10515
PF12924
PF12925
PH_hs_0010546
PR00203
PR00204
PR00759
S45136
S60317
S60721
S61380
S61383
SM00006
SM00131
TC21000340.hg
TC21000887.hg
uc002ylz.4
uc002yma.4
uc002ymb.4
uc010glj.4
uc010glk.4
uc021whz.2
UPI000002A2F2
UPI000002A2F6
UPI000002A2F7
UPI000002DB1C
UPI00001BE539
UPI00017A7091
X06981
X06982
X06989
X13466
X13467
X13468
X13469
X13470
X13471
X13472
X13473
X13474
X13475
X13476
X13477
X13478
X13479
X13487
X13488
Y00264
Y00264_at
Participant Of
Other forms of this molecule
Inferred To
Cross References
UCSC human
ZINC - Substances
GeneCards
ZINC - Biogenic
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.992 P05067 A4_HUMAN 104
0.728 O00213 APBB1_HUMAN 5
0.718 P61812 TGFB2_HUMAN 7
0.663 P10636 TAU_HUMAN 9
0.641 P04156 PRIO_HUMAN 3
0.641 P01137 TGFB1_HUMAN 3
0.633 Q9UQF2 JIP1_HUMAN 4
0.632 P49768 PSN1_HUMAN 6
0.625 Q99714 HCD2_HUMAN 4
0.625 P02647 APOA1_HUMAN 5
0.611 O75509 TNR21_HUMAN 3
0.589 Q9NP59 S40A1_HUMAN 5
0.589 P29353 SHC1_HUMAN 6
0.581 Q13625 ASPP2_HUMAN 3
0.581 O75955 FLOT1_HUMAN 5
0.564 P27797 CALR_HUMAN 2
0.564 P07196 NFL_HUMAN 2
0.564 Q99683 M3K5_HUMAN 2
0.558 P08138 TNR16_HUMAN 2
0.544 Q306T3 Q306T3_9ACTN 3
0.544 P15253 CALR_RABIT 3
0.528 P46933 APBB1_RAT 2
0.524 P01100 FOS_HUMAN 3
0.524 P61457 PHS_HUMAN 2
0.524 Q02410 APBA1_HUMAN 3
0.508 P21359 NF1_HUMAN 3
0.508 Q92870 APBB2_HUMAN 2
0.499 P78352 DLG4_HUMAN 2
0.499 P30101 PDIA3_HUMAN 3
0.489 P56817-1 BACE1 2
0.482 O14879 IFIT3_HUMAN 2
0.463 P36544 ACHA7_HUMAN 2
0.462 P04578 ENV_HV1H2 2