Reactome: A Curated Pathway Database

APP(18-770)

Stable Identifier
R-HSA-49335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
APP, Amyloid beta A4 protein precursor, ABPP, Alzheimer's disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, Soluble APP-alpha, S-APP- alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AID(59), Gamma-CTF(57), Gamma- secretase C-terminal fragment 57, Amyloid intracellular domain 57, AID(57), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AID(50), C31
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
APP, A4, AD1
Chain
signal peptide:1-17, chain:18-770, chain:18-687, chain:18-671, chain:18-286, chain:672-770, chain:672-713, chain:672-711, chain:688-770, peptide:688-713, peptide:688-711, chain:691-770, chain:712-770, chain:714-770, chain:721-770, chain:740-770
Reference Genes
Reference Transcript
Other Identifiers
 0001230601  11738008_s_at  11741216_x_at  11742210_a_at  11742211_x_at
 11742215_s_at  11746866_a_at  11750384_a_at  11751350_a_at  11752199_a_at
 11752200_x_at  11752481_a_at  11762804_x_at  16924551  1AAP
 1AMB  1AMC  1AML  1BA4  1BA6
 1BJB  1BJC  1BRC  1CA0  1HZ3
 1IYT  1MWP  1OWT  1QCM  1QWP
 1QXC  1QYT  1TAW  1TKN  1UO7
 1UO8  1UOA  1UOI  1X11  1Z0Q
 1ZE7  1ZE9  1ZJD  200602_at  211277_3p_x_at
 211277_x_at  214953_s_at  2BEG  2BOM  2BP4
 2FJZ  2FK1  2FK2  2FK3  2FKL
 2FMA  2G47  2IPU  2LFM  2LLM
 2LMN  2LMO  2LMP  2LMQ  2LNQ
 2LOH  2LP1  2LZ3  2LZ4  2M4J
 2M9R  2M9S  2MGT  2MJ1  2MPZ
 2MVX  2MXU  2OTK  2R0W  2WK3
 2Y29  2Y2A  2Y3J  2Y3K  2Y3L
 351  3927225  3927227  3927228  3927229
 3927230  3927233  3927234  3927237  3927241
 3927242  3927262  3927264  3927271  3927272
 3927273  3927274  3927281  3927282  3927289
 3927298  3927300  3927301  3927306  3927307
 3927320  3927335  3927336  3927337  3AYU
 3BAE  3BKJ  3DXC  3DXD  3DXE
 3GCI  3IFL  3IFN  3IFO  3IFP
 3JQ5  3JQL  3JTI  3KTM  3L33
 3L81  3MOQ  3MXC  3MXY  3NYJ
 3NYL  3OVJ  3OW9  3SV1  3U0T
 3UMH  3UMI  3UMK  41136_s_at  4HIX
 4JFN  4M1C  4MDR  4MVI  4MVK
 4MVL  4NGE  4OJF  4ONF  4ONG
 4PQD  4PWQ  4XXD  5AEF  5AM8
 5AMB  5C67  5CSZ  5HOW  5HOX
 5HOY  64309_f_at  8069644  A0A140VJC8  A_24_P314159
 A_33_P3296479  A_33_P3508822  AAA35540  AAA51564  AAA51722
 AAA51726  AAA51727  AAA51768  AAA58727  AAA60163
 AAB23646  AAB26263  AAB26264  AAB26265  AAB59501
 AAB59502  AAC13654  AAC60601  AAH04369  AAH65529
 AAQ14327  AAW82435  AB066441  AEE60915  AF282245
 AK295621  AK312326  AP001439  AP001440  AP001441
 AP001442  AP001443  APP  APP-001  APP-002
 APP-003  APP-004  APP-016  APP-017  AY919674
 BAA22264  BAB71958  BAG35248  BAG58500  BC004369
 BC065529  CAA30041  CAA30042  CAA30050  CAA31830
 CAA68374  CAB000157  CCDS13576  CCDS13577  CCDS33523
 CCDS46638  CCDS56212  CCDS56213  cg03779431  cg25314245
 CH471079  D87675  EAX09958  EAX09959  EAX09960
 EAX09961  EAX09963  EAX09965  ENSG00000142192  ENSP00000284981
 ENSP00000345463  ENSP00000346129  ENSP00000350578  ENSP00000351796  ENSP00000387483
 ENST00000346798  ENST00000348990  ENST00000354192  ENST00000357903  ENST00000358918
 ENST00000440126  EntrezGene:351  g4502166_3p_at  GE57419  HGNC:620
 HM005315  HPA001462  Hs.177486.2.A1_3p_a_at  Hs.434980  ILMN_1653283
 ILMN_1678152  ILMN_2404063  ILMN_2404065  IPR002223  IPR008154
 IPR008155  IPR011178  IPR013803  IPR015849  IPR019543
 IPR019744  IPR019745  IPR020901  IPR024329  IPR028866
 M15532  M15533  M16765  M18734  M24546
 M24547  M28373  M29269  M29270  M33112
 M34862  M34863  M34864  M34865  M34866
 M34867  M34868  M34869  M34870  M34871
 M34872  M34873  M34874  M34875  M34876
 M34877  M34878  M34879  M35675  M37895
 M37896  MIM:104300  MIM:104760  MIM:605714  NM_000484
 NM_001136016  NM_001136129  NM_001204301  NM_001204302  NM_001204303
 NM_201413  NM_201414  NP_000475  NP_001129488  NP_001129601
 NP_001191230  NP_001191231  NP_001191232  NP_958816  NP_958817
 PF00014  PF02177  PF03494  PF10515  PF12924
 PF12925  PH_hs_0010546  PR00203  PR00204  PR00759
 S45136  S60317  S60721  S61380  S61383
 SM00006  SM00131  TC21000340.hg  TC21000887.hg  uc002ylz.4
 uc002yma.4  uc002ymb.4  uc010glj.4  uc010glk.4  uc021whz.2
 UPI000002A2F2  UPI000002A2F6  UPI000002A2F7  UPI000002DB1C  UPI00001BE539
 UPI00017A7091  X06981  X06982  X06989  X13466
 X13467  X13468  X13469  X13470  X13471
 X13472  X13473  X13474  X13475  X13476
 X13477  X13478  X13479  X13487  X13488
 Y00264  Y00264_at
Participant Of
Other forms of this molecule
Inferred To
Cross References
UCSC human
ZINC_target
GeneCards
PRO
HMDB_protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.992 P05067 A4_HUMAN 104
0.728 O00213 APBB1_HUMAN 5
0.718 P61812 TGFB2_HUMAN 7
0.663 P10636 TAU_HUMAN 9
0.641 P04156 PRIO_HUMAN 3
0.641 P01137 TGFB1_HUMAN 3
0.633 Q9UQF2 JIP1_HUMAN 4
0.632 P49768 PSN1_HUMAN 6
0.625 Q99714 HCD2_HUMAN 4
0.625 P02647 APOA1_HUMAN 5
0.611 O75509 TNR21_HUMAN 3
0.589 Q9NP59 S40A1_HUMAN 5
0.589 P29353 SHC1_HUMAN 6
0.581 Q13625 ASPP2_HUMAN 3
0.581 O75955 FLOT1_HUMAN 5
0.564 P27797 CALR_HUMAN 2
0.564 Q99683 M3K5_HUMAN 2
0.564 P07196 NFL_HUMAN 2
0.558 P08138 TNR16_HUMAN 2
0.544 Q306T3 Q306T3_9ACTN 3
0.544 P15253 CALR_RABIT 3
0.528 P46933 APBB1_RAT 2
0.524 P01100 FOS_HUMAN 3
0.524 P61457 PHS_HUMAN 2
0.524 Q02410 APBA1_HUMAN 3
0.508 P21359 NF1_HUMAN 3
0.508 Q92870 APBB2_HUMAN 2
0.499 P78352 DLG4_HUMAN 2
0.499 P30101 PDIA3_HUMAN 3
0.489 P56817-1 BACE1 2
0.482 O14879 IFIT3_HUMAN 2
0.463 P36544 ACHA7_HUMAN 2
0.462 P04578 ENV_HV1H2 2