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Presynaptic function of Kainate receptors

Stable Identifier
R-HSA-500657
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Kainate receptors in the presynaptic neuron are involved in modulating the release of neurotransmitters like glutamate and gamma amino butyric acid (GABA). This activity of Kainate receptors is independent of ionic fluxes through the channel. Homomeric kainate receptors containing GRIK3 are shown to be involved in this process. Kainate receptors in these neurons bind G-protein coupled receptors that activate phospholipase C which eventually triggers the release of Ca2+ from the intracellular stores. The released Ca2+ further initiates the fusion and release of vesicles containing the neurotransmitter.

Literature References
PubMed ID Title Journal Year
20007474 Atypical functional properties of GluK3-containing kainate receptors J Neurosci 2009
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