Reactome: A Curated Pathway Database
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GPCR ligand binding

Stable Identifier
R-HSA-500792
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

There are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all physiological processes (Frederiksson 2003). GPCRs are receptors for a diverse range of ligands from large proteins to photons (Kristiansen et al. 2004) and have an equal diversity of ligand-binding mechanisms (Gether et al. 2002). Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported.

Literature References
Participants
Participant Of
Orthologous Events