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pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]

Stable Identifier
R-HSA-507749
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
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Summation

Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2] (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
L-alanine:2-oxoglutarate aminotransferase activity of GPT2 dimer [mitochondrial matrix]
Physical Entity
GPT2 dimer [mitochondrial matrix]
Activity
L-alanine:2-oxoglutarate aminotransferase activity (0004021)
Orthologous Events
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Arabidopsis thaliana)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Bos taurus)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Caenorhabditis elegans)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Canis familiaris)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Danio rerio)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Dictyostelium discoideum)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Drosophila melanogaster)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Gallus gallus)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Mus musculus)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Oryza sativa)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Rattus norvegicus)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Saccharomyces cerevisiae)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Schizosaccharomyces pombe)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Sus scrofa)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Taeniopygia guttata)
pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (Xenopus tropicalis)
Cross References
Rhea