Reactome: A Curated Pathway Database

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2] (R-HSA-507749) [Homo sapiens]


Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

Additional Information
Compartment mitochondrial matrix
Reverse Reaction alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
GPT2 dimer L-alanine:2-oxoglutarate aminotransferase activity (0004021)