Reactome: A Curated Pathway Database

pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]

Stable Identifier
R-HSA-507749
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-alanine:2-oxoglutarate aminotransferase activity of GPT2 dimer [mitochondrial matrix] GPT2 dimer [mitochondrial matrix] L-alanine:2-oxoglutarate aminotransferase activity (0004021)
Orthologous Events