Glutamic-pyruvate transaminase 2 (alanine aminotransferase 2) (GPT2) catalyzes the reversible reaction of pyruvate and glutamate to form alanine and 2-oxoglutarate (alpha-ketoglutarate) (Yang et al. 2002). Unpublished crystallographic data are consistent with a homodimeric structure for the enzyme with one molecule of pyridoxal phosphate associated with each monomer (PDB 3IHJ). Recent studies of organelles purified from cultured human muscle cells suggest that GPT2 is localized to mitochondria (Glinghammar et al. 2009).
|Reverse Reaction||alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]|
|GPT2 dimer||L-alanine:2-oxoglutarate aminotransferase activity (0004021)|
|19360321||Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma||Int J Mol Med||2009|
|11863375||cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase||Genomics||2002|