Reactome: A Curated Pathway Database

Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36) (R-MMU-508217)

Species Mus musculus

Summation

Prohormone convertase 1 (PC1/3, NEC, Pcsk1) cleaves proglucagon adjacent to amino acids 98 and 127 to yield Glucagon-like peptide-1 (7-36).

Locations in the PathwayBrowser
Additional Information
Compartment secretory granule lumen
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Pcsk1 serine-type endopeptidase activity (0004252)
Literature References
pubMedId Title Journal Year
12145326 Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects Proc Natl Acad Sci U S A 2002