Reactome: A Curated Pathway Database

Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36)

Stable Identifier
R-MMU-508217
Type
Reaction
Species
Mus musculus
Compartment
Locations in the PathwayBrowser
Summation

Prohormone convertase 1 (PC1/3, NEC, Pcsk1) cleaves proglucagon adjacent to amino acids 98 and 127 to yield Glucagon-like peptide-1 (7-36).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of Pcsk1 [secretory granule lumen] Pcsk1 [secretory granule lumen] serine-type endopeptidase activity (0004252)
Orthologous Events