Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

Pcsk1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 (7-36)

Stable Identifier
R-MMU-508217
Type
Reaction
Species
Mus musculus
Compartment
Locations in the PathwayBrowser
Summation

Prohormone convertase 1 (PC1/3, NEC, Pcsk1) cleaves proglucagon adjacent to amino acids 98 and 127 to yield Glucagon-like peptide-1 (7-36).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of Pcsk1 [secretory granule lumen] Pcsk1 [secretory granule lumen] serine-type endopeptidase activity (0004252)
Orthologous Events