Reactome | Gab2 binds the p85 subunit of Class 1A PI3 kinases

Gab2 binds the p85 subunit of Class 1A PI3 kinases

Stable Identifier

R-HSA-508247

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Gab2 binds the p85 subunit of Class 1A PI3 kinases

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Shc promotes Gab2 tyrosine phosphorylation via Grb2 (Gu et al. 2000). This promotes binding of Gab2 to p85alpha, a component of Class 1A PI3Ks (Gu et al. 1998). JAK1 may also be involved in PI3K recruitment (Migone et al. 1998). Binding of p85 activates PI3K kinase activity, with consequent effects on many processes including Akt activation. This is one of two mechanisms described for the recruitment of PI3K to the IL-3/IL-5/GM-CSF receptors, the other is mediated by Serine-585 phosphorylation of the common beta chain.

Literature References

PubMed ID	Title	Journal	Year
10455108	Engagement of Gab1 and Gab2 in erythropoietin signaling Krystal, G, Ahmad, S, Chen, F, Sharma, A, Sawyer, ST, Platanias, LC, Nishada, K, Hirano, T, Hibi, M, Yi, T, Alsayed, Y, Uddin, S, Wickrema, A	J Biol Chem	1999
9885561	Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation Neel, BG, Pratt, JC, Gu, H, Burakoff, SJ	Mol Cell	1998