Reactome: A Curated Pathway Database

SYK is a substrate for JAK1

Stable Identifier
R-HSA-508282
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events