Reactome: A Curated Pathway Database

SYK is a substrate for JAK1 (R-HSA-508282)

Species Homo sapiens

Summation

Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IL2:IL2R trimer:p-JAK1:JAK3:SYK protein tyrosine kinase activity (0004713)