Reactome: A Curated Pathway Database

SYK is a substrate for JAK1 (R-HSA-508282) [Homo sapiens]

Reaction
Summation

Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Additional Information
Compartment plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IL2:IL2R trimer:p-JAK1:JAK3:SYK protein tyrosine kinase activity (0004713)