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SYK is a substrate for JAK1

Stable Identifier
R-HSA-508282
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events