Reactome: A Curated Pathway Database

Syk binds IL2RB

Stable Identifier
R-HSA-508292
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).
Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.

Literature References
Participants
Participant Of
Orthologous Events