Reactome: A Curated Pathway Database

Syk binds IL2RB (R-HSA-508292) [Homo sapiens]


Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).
Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.

Additional Information
Compartment cytosol , plasma membrane