Syk binds IL2RB (R-HSA-508292) [Homo sapiens]


Syk binds to the serine-rich (aa 267 to 322) S region of IL2RB and becomes activated upon IL-2 stimulation (Minami et al. 1995).
Syk is shown here binding with the IL2:IL2RB trimer:p-JAK1:JAK3 complex but it may become associated at an earlier stage of receptor activation.

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Additional Information
Compartment cytosol , plasma membrane
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Input entries
Output entries
Literature References
pubMedId Title Journal Year
7600304 Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway Immunity 1995
Inferred Entries
Orthologous events