Reactome: A Curated Pathway Database

WNT5A-dependent internalization of FZD4

Stable Identifier
R-HSA-5099900
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

WNT5A induces internalization of FZD4 in a manner that depends upon PKC-mediated phosphorylation of DVL2. Uptake of FZD4 appears to occur in a clathrin, AP-2 and ARBB2-dependent mannner (Chen et al, 2003; Yu et al, 2007; Yu et al, 2010).

Literature References
Participants
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