In chicken, TLR1 and 2 genes are individually duplicated to encode four different proteins of the TLR2 subfamily:
Analyses of chicken genome revealed that all chTLR2 and chTLR1 isoforms are located on Chromosome 4 and are encoded by one exon, like human TLR2 and TLR1. The phylogenetic comparative analysis also showed that chTLR2 isoforms are two distinct genes (not splicing products of the same gene) and TLR2A and B are both orthologs of the single TLR2 of mammals (Temperley ND et al 2008, Cormican et al 2009). Although chicken TLR1 type 1 and 2 genes were reported by Yilmaz et al. (2004) to be highly similar to human TLR1 and TLR6 genes, further analysis revealed that chicken TLR1 and human TLR1/6/10 are not orthologs (Temperley ND et al 2008).
The functional profile of chicken TLR2 subfamily proteins is similar to human; members of TLR2 subfamily respond to lipoproteins through heterodimer formation.
|GO Biological Process||toll-like receptor 2 signaling pathway (0034134)|
|18241342||Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss||BMC Genomics||2008|
|15578175||Identification and sequence analysis of chicken Toll-like receptors||Immunogenetics||2005|
|19539094||The avian Toll-Like receptor pathway--subtle differences amidst general conformity||Dev Comp Immunol||2009|