Reactome: A Curated Pathway Database

Negative epigenetic regulation of rRNA expression (R-HSA-5250941)

Species Homo sapiens


Transcription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughly 400 rRNA genes are expressed and these have the modifications of active chromatin: unmethylated DNA and acetylated histones. Repressed genes generally have methylated DNA and histone H3 methylated at lysine-9. Regulators of repression include the eNoSC complex, SIRT1, and the NoRC complex.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process negative regulation of gene expression, epigenetic (0045814)
Literature References
pubMedId Title Journal Year
18616426 The epigenetics of rRNA genes: from molecular to chromosome biology Annu Rev Cell Dev Biol 2008
23150253 Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes Subcell. Biochem. 2012
23063748 Epigenetic control of RNA polymerase I transcription in mammalian cells Biochim. Biophys. Acta 2013