Reactome: A Curated Pathway Database

Misspliced GSK3beta mutants stabilize beta-catenin

Stable Identifier
R-HSA-5339716
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show elevated levels of nuclear beta-catenin and enhanced TCF-dependent reporter activity (Jamieson et al, 2008; Abrahamsson et al, 2009).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
chronic myeloid leukemia 8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
BioModels Database