Reactome: A Curated Pathway Database

S33 mutants of beta-catenin aren't phosphorylated

Stable Identifier
R-HSA-5358747
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

S33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis, 2000). S33 mutations have been identified in cancers of the central nervous system, liver, endometrium and stomach, among others (reviewed in Polakis, 2000).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database