Phosphorylation of ITIM in SIRP alpha

Stable Identifier
R-MMU-548973
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of ITIM in SIRP alpha
Various growth factors and events such as integrin-mediated cell adhesion to extracellular matrix (ECM) proteins induce the tyrosine phosphorylation of SIRP alpha. The cytoplasmic tail of SIRP alpha has two ITIMs with four tyrosine residues that are potential sites for phosphorylation. Phosphorylation is not dependent on CD47 engagement but the presence of CD47 may enhance the effect. Src family kinases may be involved in the phosphorylation.
Literature References
PubMed ID Title Journal Year
17584740 Dual regulation of SIRPalpha phosphorylation by integrins and CD47

Brown, EJ, Johansen, ML

J Biol Chem 2007
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Unknown Src kinase [cytosol]

Physical Entity
Unknown Src kinase [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)
Authored
Garapati, P V  (2009-02-12)
Reviewed
Barclay, AN  (2010-05-20)
Created
Garapati, P V  (2010-03-15)
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