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Phosphorylation of ITIM in SIRP alpha

Stable Identifier
R-MMU-548973
Type
Reaction
Species
Mus musculus
Compartment
Summation

Various growth factors and events such as integrin-mediated cell adhesion to extracellular matrix (ECM) proteins induce the tyrosine phosphorylation of SIRP alpha. The cytoplasmic tail of SIRP alpha has two ITIMs with four tyrosine residues that are potential sites for phosphorylation. Phosphorylation is not dependent on CD47 engagement but the presence of CD47 may enhance the effect. Src family kinases may be involved in the phosphorylation.

Literature References
PubMed ID Title Journal Year
17584740 Dual regulation of SIRPalpha phosphorylation by integrins and CD47 J Biol Chem 2007
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Unknown Src kinase [cytosol]
Physical Entity
Activity
Orthologous Events