Reactome: A Curated Pathway Database

Phosphorylation of ITIM in SIRP alpha (R-MMU-548973) [Mus musculus]


Various growth factors and events such as integrin-mediated cell adhesion to extracellular matrix (ECM) proteins induce the tyrosine phosphorylation of SIRP alpha. The cytoplasmic tail of SIRP alpha has two ITIMs with four tyrosine residues that are potential sites for phosphorylation. Phosphorylation is not dependent on CD47 engagement but the presence of CD47 may enhance the effect. Src family kinases may be involved in the phosphorylation.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Unknown Src kinase protein tyrosine kinase activity (0004713)  
Literature References
pubMedId Title Journal Year
17584740 Dual regulation of SIRPalpha phosphorylation by integrins and CD47 J Biol Chem 2007