Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

Organic cation/anion/zwitterion transport

Stable Identifier
R-HSA-549132
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the major facilitator superfamily and comprises uniporters, symporters and antiporters.Most of this family are polyspecific transporters. Since many of these transporters are expressed in the liver, kidney and intestine, they play an important role in drug absorption and excretion. Substrates include xenobiotics, drugs, and endogenous amine compounds (Koepsell H and Endou H, 2004).

Literature References
PubMed ID Title Journal Year
12883891 The SLC22 drug transporter family Pflugers Arch 2004
Participants
Participant Of
Orthologous Events