Reactome: A Curated Pathway Database

Organic cation/anion/zwitterion transport (R-HSA-549132) [Homo sapiens]


The SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the major facilitator superfamily and comprises uniporters, symporters and antiporters.Most of this family are polyspecific transporters. Since many of these transporters are expressed in the liver, kidney and intestine, they play an important role in drug absorption and excretion. Substrates include xenobiotics, drugs, and endogenous amine compounds (Koepsell H and Endou H, 2004).

Literature References
pubMedId Title Journal Year
12883891 The SLC22 drug transporter family Pflugers Arch 2004