Reactome: A Curated Pathway Database

Phase 4 - resting membrane potential

Stable Identifier
R-HSA-5576886
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Phase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+ and relatively impermeable to other ions therefore the K+ gradient across the cell membrane is the key determinant in the normal resting potential (Park & Fishman 2011, Grant 2009). In this phase, K+ currents are generated by inward rectifier potassium channels (KCNJs) and tandem pore domain K+ channels (KCNKs). Some Na+/K+-ATPases and Na+/Ca2+-exchangers can also play roles during this phase.

Literature References
PubMed ID Title Journal Year
19808464 Cardiac ion channels Circ Arrhythm Electrophysiol 2009
21357845 The cardiac conduction system Circulation 2011
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Orthologous Events