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Expression of CEBPA
Stable Identifier
R-HSA-560491
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The activation of expression of CEBPA by EBF1 is inferred from mouse where Ebf1 directly binds one site in the Cebpa promoter and activates transcription of the Cebpa gene. The CEBPA gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The PPARG:RXRA heterodimer bound to fatty acids activates transcription of the CEBPA gene. In mouse the Pparg:Rxra heterodimer binds the promoter of the Cebpa gene (Lefterova et al. 2008). As inferred from mouse, TNF-alpha inhibits expression of CEBPA in pre-adipocytes. As inferred from mouse, TGF-beta inhibits expression of CEPBA in preadipocytes. As inferred from mouse 3T3-L1 cells, Wnt-1 and Wnt-10b inhibit expression of CEBPA through stabillization of beta-Catenin. Wnt-10b is probably the actual regulator in vivo.
Literature References
PubMed ID
Title
Journal
Year
16380219
Identification of novel PPARgamma target genes in primary human adipocytes
Dean, NM
,
Koo, S
,
Kim, Y
,
Marcusson, EG
,
Kang, X
,
Perera, RJ
,
White, N
Gene
2006
Participants
Input
CEBPA gene [nucleoplasm]
(Homo sapiens)
Output
CEBPA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
This event is regulated
Negatively by
Regulator
WNT1,WNT10B [extracellular region]
(Homo sapiens)
Regulator
TGFB1 [extracellular region]
(Homo sapiens)
Regulator
TNF(77-233) [extracellular region]
(Homo sapiens)
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
(Homo sapiens)
Regulator
EBF1 [nucleoplasm]
(Homo sapiens)
Inferred From
Expression of Cebpa (Mus musculus)
Authored
May, B (2010-03-23)
Reviewed
Sethi, JK (2011-02-10)
D'Eustachio, P (2009-05-27)
Created
May, B (2010-03-24)
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