Reactome: A Curated Pathway Database

VxPx cargo-targeting to cilium

Stable Identifier
R-HSA-5620916
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).

Literature References
Participants
Participant Of
Orthologous Events