Reactome: A Curated Pathway Database

Gap-filling DNA repair synthesis and ligation in GG-NER

Stable Identifier
R-HSA-5696397
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Global genome nucleotide excision repair (GG-NER) is completed by DNA repair synthesis that fills the single stranded gap created after dual incision of the damaged DNA strand and excision of the ~27-30 bases long oligonucleotide that contains the lesion. DNA synthesis is performed by DNA polymerases epsilon or delta, or the Y family DNA polymerase kappa (POLK), which are loaded to the repair site after 5' incision (Staresincic et al. 2009, Ogi et al. 2010). DNA ligases LIG1 or LIG3 (as part of the LIG3:XRCC1 complex) ligate the newly synthesized stretch of oligonucleotides to the incised DNA strand (Moser et al. 2007).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database