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Deposition of new CENPA-containing nucleosomes at the centromere (R-HSA-606279) [Homo sapiens]

Pathway
Summation

Eukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophase/early G1 phase of the cell cycle. Once deposited, nucleosomes containing CENPA remain stably associated with the centromere and are partitioned equally to daughter centromeres during S phase. A current model proposes that pre-existing CENPA at the centromere drives recruitment of new CENPA, however this has not been proved.
The deposition process requires at least 3 complexes: the Mis18 complex, HJURP complex, and the RSF complex. HJURP binds newly synthesized CENPA-H4 tetramers before deposition and brings them to the centromere for deposition in new CENPA-containing nucleosomes. The exact mechanism of deposition remains unknown.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
GO Biological Process CENP-A containing nucleosome assembly (0034080)
Literature References
pubMedId Title Journal Year
17339380 Propagation of centromeric chromatin requires exit from mitosis J Cell Biol 2007
19410544 Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP Cell 2009
19410545 HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres Cell 2009
20080577 HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres Proc Natl Acad Sci U S A 2010
19410539 Frodos found: Behold the CENP-a "Ring" bearers Cell 2009
19590885 At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly Chromosoma 2009
19660450 Epigenetic specification of centromeres by CENP-A Exp Cell Res 2009
19629040 Focus on the centre: the role of chromatin on the regulation of centromere identity and function EMBO J 2009
Inferred Entries
Orthologous events
 
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