Reactome: A Curated Pathway Database
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New CENPA-containing nucleosomes are deposited at the centromere

Stable Identifier
R-HSA-606289
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.

Literature References
Participants
Participant Of